G. G. Lavery

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

Nicotinamide Riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise

This study investigates whether NR supplementation affects metabolic responses to endurance exercise in human skeletal muscle, finding no significant changes in key metabolic markers or mitochondrial adaptation.

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake

This study identifies ARF4 and VCP as regulators of NIS trafficking and shows FDA-approved VCP inhibitors enhance radioiodine uptake in thyroid cancer cells and mice.

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice

This study examines the metabolic and mitochondrial adaptations in H6PDH knockout mice, showing activation of the NRK2 NAD+ salvage pathway and its limited effect on mitigating myopathy and mitochondrial dysfunction.