Author

V. M. Draviam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Efstathiou· 2 shared D. Conti· 2 shared M. Hart· 2 shared X. Song· 2 shared A. Islam· 1 shared A.-C. Maharea· 1 shared B. Chai· 1 shared D. Braun· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

C. Efstathiou

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Author profile →

6 papers

Recent·Most cited

Multi-SpinX: An Advanced Framework for Automated Tracking of Mitotic Spindles and Kinetochores in Multicellular Environments

B. Chai, C. Efstathiou, M. Choudhury, K. Kuniyasu, S. S. Jain, A.-C. Maharea, K. Tanaka, V. M. Draviam

The paper introduces Multi-SpinX, an AI framework that extends SpinX to track mitotic spindles and kinetochores in multicellular environments across different mitotic stages.

bioRxiv · Apr 3, 2024Cell Biology

Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteins

A. Islam, J. C. Manjarrez-Gonzalez, T. Gore, X. Song, V. M. Draviam

The paper identifies Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule proteins by analyzing LoF variants in chromosome segregation genes across 150,000 humans, revealing harmful and resilient variants.

bioRxiv · Jan 22, 2022 · PreprintCell Biology

SpinX: Time-resolved 3D Analysis of Mitotic Spindle Dynamics using Deep Learning Techniques and Mathematical Modelling

D. Dang, C. Efstathiou, D. Sun, N. Sastry, V. M. Draviam

SpinX reconstructs gaps in time-lapse microscopy movies using deep learning and mathematical modeling to enable 3D tracking of mitotic spindles with high precision.

bioRxiv · Sep 21, 2021 · PreprintCell Biology

Cells protect chromosome-microtubule attachments, independent of biorientation, using an Astrin-PP1 and CyclinB-CDK1 feedback loop

D. Conti, X. Song, R. Shrestha, D. Braun, V. M. Draviam

The paper identifies a feedback loop between Astrin-PP1 and CyclinB-CDK1 that stabilizes mono-oriented chromosome-microtubule attachments independent of biorientation.

bioRxiv · Dec 24, 2020 · PreprintCell Biology

Multinucleation Associated DNA Damage causes quiescence despite compromised p53

M. Hart, S. D. Adams, V. M. Draviam

The paper investigates how multinucleation, a form of nuclear atypia, causes quiescence in p53-compromised cells through persistent DNA damage signaling, distinct from other nuclear atypias.

bioRxiv · Dec 22, 2020 · PreprintCell Biology

MARK2/Par1b present at retraction fibres corrects spindle off-centering induced by actin disassembly

M. Hart, I. Zulkipli, R. L. Shrestha, D. D. Dang, D. Conti, I. Kujawiak, V. M. Draviam

The paper identifies MARK2/Par1b as a component of retraction fibres that corrects spindle off-centering and regulates G1-S progression.

bioRxiv · Dec 31, 2018Cell Biology