D. Braun

Prebiotic gas flow environment enables isothermal nucleic acid replication

This study demonstrates that an isothermal prebiotic gas flow environment enables exponential DNA replication by concentrating nucleic acids and reducing salt concentration.

Replication elongates short DNA, reduces sequence bias, and develops trimer structure

This study shows that replication of short biased DNA sequences reduces initial nucleotide bias and introduces periodic dimer and trimer motifs through templated polymerization.

Selection of the Early Genetic Code by Ultraviolet Light

This study quantifies UV stability of DNA sequences and simulates photodamage to proto-genomes, showing UV compatibility of early life and ranking codon evolutionary models by UV resistance.

Sequence Dependent UV Damage of Complete Pools of Oligonucleotides

The paper quantifies UV damage susceptibility of all 4096 hexamer DNA sequences using high-throughput sequencing, revealing sequence context effects on lesion formation.

A broad, exposome-type evaluation of xenobiotic phase II biotransformation in human biofluids by LC-MS/MS

The paper evaluates phase II biotransformation enzymes for xenobiotic deconjugation in human biofluids using LC-MS/MS, finding H. pomatia is most efficient overall but recombinant BGS is better for breast milk due to lower contamination.

Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells

This study shows gas bubbles in heated rock pores drive the growth, fusion, division, and selection of coacervate microdroplets, simulating early evolutionary processes of protocells.

Cells protect chromosome-microtubule attachments, independent of biorientation, using an Astrin-PP1 and CyclinB-CDK1 feedback loop

The paper identifies a feedback loop between Astrin-PP1 and CyclinB-CDK1 that stabilizes mono-oriented chromosome-microtubule attachments independent of biorientation.

Ligation of random oligomers leads to emergence of autocatalytic sequence network

This study shows how nontrivial sequence patterns emerge from random DNA strands through templated ligation and temperature cycling, resembling Darwinian evolution.

Longitudinal assessment of mycotoxin co-exposures in exclusively breastfed infants

This paper assesses mycotoxin exposure in breast milk over 211 days in a single infant, finding low concentrations of several mycotoxins with potential for chronic low-dose exposure.

CO2 reduction driven by a pH gradient

This study demonstrates CO2 reduction by H2 using pH gradients and Fe(Ni)S precipitates, producing formate and revealing an electrochemical mechanism.

Interaction between induced and natural variation at oil yellow1 delays flowering in maize

The paper shows that the interaction between induced and natural variation at the vey1 locus in maize delays flowering by affecting chlorophyll content and photosynthesis.