Author

K. van de Wetering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Perrakis· 1 shared D. Leyton-Puig· 1 shared D. Patel· 1 shared E. Matas-Rico· 1 shared F. Niaziorimi· 1 shared F. Szeri· 1 shared I. Shapiro· 1 shared K. Jalink· 1 shared

Activity by Year

2016-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. Perrakis

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Author profile →

3 papers

Recent·Most cited

Abcc6 null mice a model for mineralization disorder PXE show vertebral osteopenia without enhanced intervertebral disc calcification with aging

P. Boneski, V. Madhu, R. Tomlinson, K. Van de Wetering, I. Shapiro, M. Risbud

This study investigates ABCC6 loss-of-function in mice, showing reduced vertebral bone quality and mild disc degeneration without disc calcification, and suggests potassium citrate as a potential treatment.

bioRxiv · Nov 17, 2021Cell Biology

Ankylosis homologue mediates cellular efflux of ATP, not pyrophosphate

F. Szeri, F. Niaziorimi, S. Donnelly, N. Fariha, M. Tertyshnaia, D. Patel, S. Lundkvist, K. van de Wetering

The paper shows ANKH mediates ATP release, not PPi, and both ANKH and ABCC6 contribute to plasma PPi by extruding NTPs, not PPi directly.

bioRxiv · Aug 27, 2021Biochemistry

Negative regulation of uPAR activity by a GPI-specific phospholipase C

M. van Veen, E. Matas-Rico, K. van de Wetering, D. Leyton-Puig, K. M. Kedziora, N. Sidenius, K. Jalink, A. Perrakis, W. H. Moolenaar

This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.

bioRxiv · Dec 20, 2016Cell Biology