Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal
F. J. Roushar, A. G. McKee, C. P. Kuntz, J. T. Ortega, W. D. Penn, H. Woods, L. M. Chamness, V. Most, J. Meiler, B. Jastrzebska, J. P. Schlebach
This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.
bioRxiv · Mar 1, 2022Biochemistry