Author

H. Woods

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 6 Research Focus:protein folding & dynamics· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:protein structure· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Meiler· 6 shared A. G. McKee· 4 shared C. P. Kuntz· 4 shared J. P. Schlebach· 4 shared B. Jastrzebska· 2 shared F. J. Roushar· 2 shared J. T. Ortega· 2 shared L. M. Chamness· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiophysics

J. Meiler

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants

L. M. Chamness, C. P. Kuntz, A. G. McKee, W. D. Penn, C. M. Hemmerich, D. B. Rusch, H. Woods, Dyotima, J. Meiler, J. P. Schlebach

The paper examines how mutations in unstable membrane proteins like GnRHR form distinct epistatic interactions depending on their destabilizing mechanisms and severity.

bioRxiv · Aug 25, 2023Biochemistry

Modeling membrane geometries implicitly in Rosetta

H. Woods, J. Koehler Leman, J. Meiler

The paper modifies Rosetta's membrane energy function to model membrane geometries beyond flat bilayers, improving structure refinement and design for membrane proteins.

bioRxiv · Aug 23, 2023Biophysics

Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal

F. J. Roushar, A. G. McKee, C. P. Kuntz, J. T. Ortega, W. D. Penn, H. Woods, L. M. Chamness, V. Most, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.

bioRxiv · Mar 1, 2022Biochemistry

Towards Generalizable Predictions for the Effects of Mutations on G-Protein Coupled Receptor Expression

C. P. Kuntz, H. Woods, A. G. McKee, N. B. Zelt, J. L. Mendenhall, J. Meiler, J. P. Schlebach

This paper trains neural networks to predict how mutations affect plasma membrane expression of GPCRs, showing structural features alone can generalize across related proteins.

bioRxiv · Dec 28, 2021Biophysics

Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

A. G. McKee, C. P. Kuntz, J. T. Ortega, H. Woods, F. J. Roushar, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how temperature and retinal affect plasma membrane expression of rhodopsin variants, revealing correlations between mutation sites and sensitivity to these factors.

bioRxiv · Mar 26, 2021Biophysics

Upgraded molecular models of the human KCNQ1 potassium channel

G. Kuenze, A. M. Duran, H. Woods, K. R. Brewer, E. F. McDonald, C. G. Vanoye, A. L. George, C. R. Sanders, J. Meiler

This paper develops and validates structural models of human KCNQ1 potassium channels to understand mutation-induced dysfunction and guide drug design.

bioRxiv · May 24, 2019Biophysics