Author

A. G. McKee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 7 Approach:deep learning· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 4 Research Focus:protein folding & dynamics· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

J. P. Schlebach· 7 shared C. P. Kuntz· 6 shared F. J. Roushar· 5 shared J. Meiler· 5 shared W. D. Penn· 5 shared H. Woods· 4 shared B. Jastrzebska· 3 shared J. T. Ortega· 3 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersBiochemistry

J. P. Schlebach

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Author profile →

7 papers

Recent·Most cited

Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR Variant

P. Carmody, F. J. Roushar, A. Tedman, W. Wang, M. Herwig, M. Kim, E. F. McDonald, K. Noguera, J. Wong-Roushar, J.-L. Poirier, N. Zelt, B. Pockrass, A. G. McKee, C. P. Kuntz, S. V. Raju, , J. P. Schlebach

This paper identifies an RNA structure in the CFTR transcript that promotes ribosomal frameshifting and premature termination, enhancing the function and pharmacological rescue of the misfolded {Delta}F508 CFTR variant.

Proceedings of the National Academy of Sciences · Oct 10, 2024Peer-reviewedBiochemistry

Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants

L. M. Chamness, C. P. Kuntz, A. G. McKee, W. D. Penn, C. M. Hemmerich, D. B. Rusch, H. Woods, Dyotima, J. Meiler, J. P. Schlebach

The paper examines how mutations in unstable membrane proteins like GnRHR form distinct epistatic interactions depending on their destabilizing mechanisms and severity.

bioRxiv · Aug 25, 2023Biochemistry

Elucidation of Global Trends in the Effects of VX-661 and VX-445 on the Expression of Clinical CFTR Variants

A. G. McKee, E. F. McDonald, W. D. Penn, C. P. Kuntz, K. Noguera, L. M. Chamness, F. J. Roushar, J. Meiler, K. E. Oliver, L. Plate, J. P. Schlebach

This study compares the effects of VX-661 and VX-445 on 129 CFTR variants using deep mutational scanning, finding distinct patterns of expression rescue based on variant destabilization and binding pocket locations.

bioRxiv · Oct 14, 2022 · PreprintBiochemistry

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

J. T. Ortega, A. G. McKee, F. J. Roushar, W. D. Penn, J. P. Schlebach, B. Jastrzebska

This study identifies a chromenone derivative that stabilizes rod opsin mutants, rescues membrane trafficking in vitro, and protects photoreceptors in vivo in RP models.

bioRxiv · Apr 5, 2022Pharmacology & Toxicology

Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal

F. J. Roushar, A. G. McKee, C. P. Kuntz, J. T. Ortega, W. D. Penn, H. Woods, L. M. Chamness, V. Most, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.

bioRxiv · Mar 1, 2022Biochemistry

Towards Generalizable Predictions for the Effects of Mutations on G-Protein Coupled Receptor Expression

C. P. Kuntz, H. Woods, A. G. McKee, N. B. Zelt, J. L. Mendenhall, J. Meiler, J. P. Schlebach

This paper trains neural networks to predict how mutations affect plasma membrane expression of GPCRs, showing structural features alone can generalize across related proteins.

bioRxiv · Dec 28, 2021Biophysics

Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

A. G. McKee, C. P. Kuntz, J. T. Ortega, H. Woods, F. J. Roushar, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how temperature and retinal affect plasma membrane expression of rhodopsin variants, revealing correlations between mutation sites and sensitivity to these factors.

bioRxiv · Mar 26, 2021Biophysics