Author

J. T. Ortega

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:experimental assay· 1

Frequent Co-Authors

A. G. McKee· 3 shared B. Jastrzebska· 3 shared F. J. Roushar· 3 shared J. P. Schlebach· 3 shared C. P. Kuntz· 2 shared H. Woods· 2 shared J. Meiler· 2 shared W. D. Penn· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. G. McKee

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

J. T. Ortega, A. G. McKee, F. J. Roushar, W. D. Penn, J. P. Schlebach, B. Jastrzebska

This study identifies a chromenone derivative that stabilizes rod opsin mutants, rescues membrane trafficking in vitro, and protects photoreceptors in vivo in RP models.

bioRxiv · Apr 5, 2022Pharmacology & Toxicology

Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal

F. J. Roushar, A. G. McKee, C. P. Kuntz, J. T. Ortega, W. D. Penn, H. Woods, L. M. Chamness, V. Most, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.

bioRxiv · Mar 1, 2022Biochemistry

Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

A. G. McKee, C. P. Kuntz, J. T. Ortega, H. Woods, F. J. Roushar, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how temperature and retinal affect plasma membrane expression of rhodopsin variants, revealing correlations between mutation sites and sensitivity to these factors.

bioRxiv · Mar 26, 2021Biophysics