Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer
K. Balamurugan, S. Sehareen, S. Sharan, S. Krishnamurthy, W. Tang, L. McKennett, V. Padmanaba, K. T. Czarra, A. J. Ewald, S. Ambs, N. T. Ueno, D. K. Poria, E. Sterneck
This study identifies COX-2/GSK3β signaling as a mechanism maintaining E-cadherin adhesions in metastatic breast cancer, showing that targeting this pathway reduces metastasis and improves outcomes.
bioRxiv · Jan 18, 2022Cancer Biology