Author

V. Sikirzhytski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Chumanevich· 1 shared B. Gyorffy· 1 shared C. Cheng· 1 shared C. E. Dowling· 1 shared C. McInnes· 1 shared C.-u. Lim· 1 shared D. C. Porter· 1 shared E. V. Broude· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. A. Chumanevich

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2 papers

Recent·Most cited

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

J. Li, T. A. Hilimire, Y. Liu, L. Wang, J. Liang, B. Gyorffy, V. Sikirzhytski, H. Ji, L. Zhang, C. Cheng, X. Ding, K. R. Kerr, C. E. Dowling, A. A. Chumanevich, G. P. Schools, , M. Chen

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

bioRxiv · Aug 8, 2023Cancer Biology

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

O. Saatci, O. Akbulut, M. Cetin, V. Sikirzhytski, O. Sahin

This study identifies TACC3 as a therapeutic target in breast cancers with centrosome amplification, showing its inhibition leads to apoptosis and growth suppression in organoids and xenografts.

bioRxiv · May 18, 2022Cancer Biology