O. Sahin

Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

This study identifies LINC00152 as a driver of tamoxifen resistance in ER+ breast cancer by inhibiting ferroptosis, and shows that targeting LINC00152 restores sensitivity to tamoxifen.

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.

Hexokinase 1b is a novel target for non-small-cell lung cancer

This study identifies HK1b as a novel therapeutic target in NSCLC by showing its role in glycolysis, tumor progression, and cisplatin resistance.

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

This study identifies TACC3 as a therapeutic target in breast cancers with centrosome amplification, showing its inhibition leads to apoptosis and growth suppression in organoids and xenografts.

A model screening pipeline for bile acid converting anti-Clostridioides difficile bacteria reveals unique biotherapeutic potential of Peptacetobacter hiranonis

The paper develops a screening pipeline to identify bile acid converting bacteria with anti-C. difficile properties, isolating Peptacetobacter hiranonis with unique biotherapeutic potential.

Coordinated regulation of WNT/β-catenin, c-Met, and Integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

This study identifies miR-193b as a key regulator of WNT/β-catenin, c-Met, and integrin pathways in TNBC, showing its strong repressive effect on metastatic traits.

Extreme stiffness of neuronal synapses and implications for synaptic adhesion and plasticity

This study measures synaptic stiffness using a combined microscopy platform and finds it to be extremely high, correlated with spine size, and potentially regulated by neural circuit processes.

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

This study identifies thymidylate synthase (TS) as a driver of epithelial-to-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC), linking it to metastasis, chemotherapy resistance, and survival.

Genetic characterization of Streptococcus equi subspecies zooepidemicus associated with high swine mortality in United States

The paper characterizes S. zooepidemicus isolates from swine mortality outbreaks in the US, identifying genomic features linked to high mortality.

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers

This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.