Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia
K. Oyama, V. Zeeb, T. Yamazawa, T. Murayama, H. Oyamada, Y. Harada, N. Fukuda, S. Ishiwata, M. Suzuki
The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.
bioRxiv · Oct 29, 2020 · PreprintBiophysics