K. Oyama

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

Relationship between Protein Conformational Stability and Its Immunogenicity When Administering Antigens to Mice Using Adjuvants

This study examines how protein conformational stability affects immunogenicity in mice when antigens are administered with adjuvants, focusing on the CH2 domain.

Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors

This study identifies four transcription factors that enhance hepatocyte differentiation from liver ductal organoids, improving their functionality and reducing cholangiocyte characteristics.

Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.

This study expresses and purifies recombinant Pvs25 from silkworms, demonstrating its potential as a malaria transmission-blocking vaccine candidate with high immunogenicity.

Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia

The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.

Synechocystis KaiC3 displays temperature and KaiB dependent ATPase activity and is important for growth in darkness

This study characterizes KaiC3 ATPase activity in Synechocystis, showing temperature dependence and interaction with KaiB proteins, and links it to growth in darkness.

Elasticity and Topography-Controlled Collagen Hydrogels Mimicking Native Cellular Milieus

This study develops collagen hydrogels that mimic native ECM by combining elasticity, topography, and composition, showing topography overrides elasticity in controlling cell morphology.