Endotoxemia and TLR4 via tissue resident macrophages triggers anemia in mouse model of colitis
Kavita Bisht, Svetlana Shatunova, Valérie Barbier, Alnaz Husseinzoda, Ran Wang, Shrutika Mate, Ruiqing Zhong, Rabina Giri, Anna S. Amiss, Kylie A. Alexander, Susan Marie Millard, Ingrid G. Winkler, Yoon‐Kyo An, Jakob Begun, Jean-Pierre Lévesque
This study shows that endotoxemia via TLR4-expressing tissue-resident macrophages contributes to anemia in a mouse model of colitis, suggesting TLR4 as a therapeutic target.
bioRxiv · Aug 30, 2026 · PreprintImmunology