Rabina Giri

Endotoxemia and TLR4 via tissue resident macrophages triggers anemia in mouse model of colitis

This study shows that endotoxemia via TLR4-expressing tissue-resident macrophages contributes to anemia in a mouse model of colitis, suggesting TLR4 as a therapeutic target.

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

Microbial Immunomodulatory Function is Altered in Inflammatory Bowel Disease Independent of Microbial Composition

This study shows that the microbiome in IBD patients has increased pro-inflammatory activity, even when microbial composition is similar to non-IBD controls.

Bioactive produced by Enterococcus Faecalis targets IL-23 signalling and protects against colitis and joint disease

This study identifies a bioactive compound from Enterococcus faecalis that suppresses IL-23 signaling and reduces inflammation in gut and joint diseases.

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.