Jakob Begun

This study shows that endotoxemia via TLR4-expressing tissue-resident macrophages contributes to anemia in a mouse model of colitis, suggesting TLR4 as a therapeutic target.

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

This study shows that the microbiome in IBD patients has increased pro-inflammatory activity, even when microbial composition is similar to non-IBD controls.

This study identifies a bioactive compound from Enterococcus faecalis that suppresses IL-23 signaling and reduces inflammation in gut and joint diseases.

This paper identifies microbiome-derived therapeutics for IBD using a metagenome-guided approach, showing improved disease markers and safety in preclinical models.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

This study identifies genetic heterogeneity in ulcerative colitis by analyzing genome-wide associations in mild and severe cases, finding distinct risk variants and a genetic risk score with no difference between mild and severe disease.