The phosphoinositide PI5P impairs mitochondrial function through endosome-mitochondria proximity
Hélène Tronchère, Sourour Ben Harzallah, Mathieu Cinato, Valentin Antoszewski, Vanessa Soldan, Stéphanie Balor, Oksana Kunduzova, Frank Lezoualc’h, Frédéric Boal
This study shows that PI5P causes mitochondrial fragmentation and dysfunction in cardiomyocytes under metabolic stress, linking endolysosomal signaling to mitochondrial metabolism.
bioRxiv · Sep 22, 2025 · PreprintCell Biology