Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents
Tamara Bernauer, Valentin Nitsche, Jesko Kaiser, Christoph G. W. Gertzen, Georg C. Höfner, Karin V. Niessen, Thomas Seeger, Dirk Steinritz, Franz Worek, Holger Gohlke, Klaus T. Wanner, Franz F. Paintner
This study synthesizes and evaluates new MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after nerve agent intoxication, identifying more potent compounds than MB327.
Toxicology Letters · May 15, 2024Peer-reviewedPharmacology & Toxicology