Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome
Rochelle L. Coulson, Valentina Frattini, Caitlin E. Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo, Gordon X. Wang
This study shows that ISRIB, a translational modulator, alleviates synaptic and behavioral issues in Fragile X syndrome by rescuing molecular and synaptic deficits in Fmr1 knockout mice.
bioRxiv · Sep 8, 2023 · PreprintNeuroscience