Yi Zuo

This paper introduces a mechanically-mediated low-pressure poration method for efficient, cargo-agnostic intracellular delivery with high throughput and clinical scalability.

This study investigates how 5-HT2AR signaling in L5 PyrNs contributes to psilocybin-induced synaptic remodeling versus hallucinations in rodents.

This study identifies aIC-to-mPFC neural circuitry as critical for cognitive flexibility and shows that targeting this pathway can restore cognitive flexibility in stressed mice.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

This study shows that ISRIB, a translational modulator, alleviates synaptic and behavioral issues in Fragile X syndrome by rescuing molecular and synaptic deficits in Fmr1 knockout mice.

This study examines synapse-type and astrocytic changes in a FXS mouse model, revealing layer-specific synaptic density alterations and reduced astrocytic association in excitatory synapses.

This paper develops GACh sensors, genetically-encoded fluorescent indicators for acetylcholine, validated across multiple cell types and species, revealing new insights into cholinergic transmission.