Rochelle L. Coulson

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

This study shows that ISRIB, a translational modulator, alleviates synaptic and behavioral issues in Fragile X syndrome by rescuing molecular and synaptic deficits in Fmr1 knockout mice.

Epigenomic convergence of genetic and immune risk factors in neurodevelopmental disorder cortex

The paper identifies epigenomic signatures in NDD cortex samples, revealing shared regulatory functions and enrichment for genetic risk factors across different NDD types.

Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study

The paper identifies two placental DNA methylation markers, CYP2E1 and IRS2, associated with ASD risk and modulated by genetic and environmental factors.

Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN

This study shows that Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN, and exogenous expression alone cannot rescue the genetic deficiency of Snord116 paternal deletion.

Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

This study identifies Snord116-dependent diurnal DNA methylation rhythms in mouse cortex and shows their disruption in Prader-Willi syndrome.

Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches

The paper investigates how augmented maternal care affects DNA methylation, gene expression, and miRNA levels in the developing hypothalamus, identifying genes linked to stress resilience.