Philippe Mourrain

Engulfment by brain macrophages in a short-lived vertebrate

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

Divergence in skeletal muscle growth by differential spatial hyperplastic patterning in teleost fishes

The paper compares muscle growth dynamics across teleost fish species, identifying spatial hyperplastic patterning and stem cell gene expression as key factors in growth differences.

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

This study shows that ISRIB, a translational modulator, alleviates synaptic and behavioral issues in Fragile X syndrome by rescuing molecular and synaptic deficits in Fmr1 knockout mice.

Haplotype-phased common marmoset embryonic stem cells for genome editing using CRISPR/Cas9

This study provides haplotype-resolved genome characterization of a marmoset ESC line and demonstrates CRISPR/Cas9 targeting and neuronal differentiation capabilities.

Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model

The paper investigates the molecular effects of 16p11.2 CNVs on gene expression and DNA methylation using an iPSC-to-iN model and identifies potential contributing genes.