Targeted Engineering of Human MxA Yields a Broad-Spectrum Super-Restrictor of Human-Adapted Influenza Viruses
Megan E. Levy, Rechel Geiger, Luc America Chi, Peter A. Dietzen, Valentina Wagner, Michael Emerman, Jagdish Suresh Patel, Laura Graf, Harmit Singh Malik
This study engineered hMxA to restrict multiple human-adapted influenza viruses as effectively as mMx1 by combining nuclear relocalization and specific amino acid changes.
bioRxiv · Oct 23, 2026 · PreprintMicrobiology