Rechel Geiger

Targeted Engineering of Human MxA Yields a Broad-Spectrum Super-Restrictor of Human-Adapted Influenza Viruses

This study engineered hMxA to restrict multiple human-adapted influenza viruses as effectively as mMx1 by combining nuclear relocalization and specific amino acid changes.

Structural modeling and experimental validation define the MxA-Thogotovirus nucleoprotein interface that drives restriction and escape

The paper defines the MxA-Thogotovirus nucleoprotein interface using structural modeling and experimental validation, revealing key residues involved in restriction and escape.

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction

The paper identifies strategies for MxA to overcome breadth-specificity tradeoffs in antiviral restriction by using heterozygous and generalist super-restrictor variants.