Author

Laura Graf

University of FreiburgORCID 0000-0002-5890-4147Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Harmit Singh MalikiD· 2 shared Michael EmermaniD· 2 shared Rechel GeigeriD· 2 shared Damini Khera· 1 shared Georg KochsiD· 1 shared Jagdish Suresh PateliD· 1 shared Jeannette L. TenthoreyiD· 1 shared Luc America ChiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Harmit Singh MalikORCID

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2 papers

Recent·Most cited

Targeted Engineering of Human MxA Yields a Broad-Spectrum Super-Restrictor of Human-Adapted Influenza Viruses

Megan E. Levy, Rechel Geiger, Luc America Chi, Peter A. Dietzen, Valentina Wagner, Michael Emerman, Jagdish Suresh Patel, Laura Graf, Harmit Singh Malik

This study engineered hMxA to restrict multiple human-adapted influenza viruses as effectively as mMx1 by combining nuclear relocalization and specific amino acid changes.

bioRxiv · Oct 23, 2026 · PreprintMicrobiology

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction

Rechel Geiger, Damini Khera, Jeannette L. Tenthorey, Georg Kochs, Laura Graf, Michael Emerman, Harmit Singh Malik

The paper identifies strategies for MxA to overcome breadth-specificity tradeoffs in antiviral restriction by using heterozygous and generalist super-restrictor variants.

Science Advances · May 2, 2025Peer-reviewedMicrobiology