Neutralizing Activity of Cervicovaginal Secretions against Herpes Simplex Virus is Mediated by Mucosal IgG and Viral Glycoprotein E and Adversely Impacted by Vaginal Dysbiosis
Aakash Mahant Mahant, Valerie Fong, Matthew S. Gromisch, Richard Hunte, Ian Michael, Jennifer T. Aguilan, Kerry Murphy, Marla J. Keller, Betsy C. Herold
This study shows that cervicovaginal secretions neutralize HSV through mucosal IgG and gE interactions, which are reduced in bacterial vaginosis due to glycan loss.
bioRxiv · May 15, 2025 · PreprintMicrobiology