A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additive effects against stress
Briana K. Chen, Michelle Jin, Gergely F. Turi, Victor M. Luna, Abhishek Shah, Taylor Moniz, Margaret E. Shannon, Michaela M Pauers, Brenna L. Williams, Vananh Pham, Holly C. Hunsberger, Alain Michel Gardier, Indira Mendez‐David, Denis Joseph Paul David, Christine Ann Denny
This study investigates the combined effects of (R,S)-ketamine and prucalopride on stress-induced behaviors and neural activity, finding additive benefits in reducing fear, despair, and hyponeophagia.
Biological Psychiatry · Oct 1, 2025Peer-reviewedNeuroscience