Denis Joseph Paul David

The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.

This study investigates the combined effects of (R,S)-ketamine and prucalopride on stress-induced behaviors and neural activity, finding additive benefits in reducing fear, despair, and hyponeophagia.

This study examines neural activity in the basolateral and central amygdala during reward seeking under punishment, finding that opposing neuronal populations in the CeA control reward-seeking behavior despite adverse consequences.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

The paper shows that doublecortin (DCX) expression does not linearly correlate with adult hippocampal neurogenesis (AHN) in various models, highlighting the need for caution in using DCX as a proxy for AHN.

This study investigates the role of GABAA, AMPA receptors and GLT-1 transporter in ketamine's antidepressant effects using mouse models.

This study tests if 5-HT4R agonists can prevent stress-induced behaviors in mice, finding that some are effective as prophylactics.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.