Engineering cathepsin S selective chemical probes and antibody-drug conjugates through substrate profiling with unnatural amino acids
Maria Łęcka, Oliwia Gorzeń, Natalia Ćwilichowska-Puślecka, Julia Nguyen, Martyna Majchrzak, Vanessa Pippa, Piotr Jakimowicz, Jerzy Ł. Wiśniewski, Bartosz Dołęga-Kozierowski, Piotr Kasprzak, Boris Turk, Marcin Drąg, Rafał Matkowski, Marcin Poręba
The paper develops selective chemical probes and antibody-drug conjugates for cathepsin S by profiling substrate specificity with unnatural amino acids and validates their efficacy in cancer models.
Journal of Medicinal Chemistry · Jul 1, 2026Peer-reviewedCancer Biology