Marcin Drąg

The paper develops selective chemical probes and antibody-drug conjugates for cathepsin S by profiling substrate specificity with unnatural amino acids and validates their efficacy in cancer models.

This paper develops a fluorogenic substrate for Chikungunya virus protease (nsP2) that improves signal-to-noise ratio and specificity for inhibitor screening.

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

The paper develops activity-based probes to selectively detect USP18 activity and screen for inhibitors, enabling analysis of USP18's role in disease states.