Prior to Undergoing Epithelial to Mesenchymal Transition, Premalignant Cells Transiently Increase Tensile Forces at Cell-Cell and Cell-Matrix Adhesions
Lídia Dornelas de Faria, Carine M Gonçalves, Inês Fidalgo, Carla S. Lopes, Vanessa Rodrigues, Maria M. Azevedo, Paula Sampaio, Sandra Tavares, Vaibhav Mahajan, Anna Verena Taubenberger, Florence Janody
The paper shows that premalignant cells increase tensile forces at cell-cell and cell-matrix adhesions before losing them, promoting proliferation and malignant transformation.
bioRxiv · Jul 5, 2025 · PreprintCancer Biology