Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Meghan M. Capeling, Bob Chen, Kazeera Aliar, Elisa Penna, Veronica Ibarra Lopez, Conrad Foo, Sandra Rost, Loryn L. Holokai, Xinming Tong, Devan Phillips, Caden W. Sweet, Jing Li, Sharmila Chatterjee, Elizabeth Skippington, Zora D. Modrusan, , Michelle B. Chen
The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.
Nature Communications · Jan 9, 2026Peer-reviewedBioengineering