Michelle B. Chen

Soma-seq links intracellular protein states to transcriptional programs in the human brain

Soma-seq measures both RNA and intracellular proteins in single human brain cells, revealing protein states linked to transcriptional programs in Alzheimer's disease.

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory

The paper uses spatial and single-cell transcriptomics to identify memory-specific transcriptional signatures in neurons and astrocytes of the basolateral amygdala, revealing their role in long-term memory formation.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

Persistent transcriptional programs are associated with remote memory in diverse cells of the medial prefrontal cortex

The paper identifies persistent transcriptional changes in diverse cells of the medial prefrontal cortex associated with remote memory, including neurons, astrocytes, and microglia.

Brain endothelial cells are exquisite sensors of age-related circulatory cues

This study uses single-cell RNA sequencing to show that brain endothelial cells respond to circulatory cues of aging, with aged plasma inducing aging transcriptomes and young plasma reversing them.

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.