Kazeera Aliar

This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.

The paper models DNA replication fork stability using chromatin fiber analysis and the R-ODD-BLOBS program, showing changes in fork length and protein localization in different genetic backgrounds.

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.