Author

Loryn L. Holokai

GenentechORCID 0000-0002-3611-9535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Mary E. KeiriD· 2 shared Aaron T. L. LuniD· 1 shared Aditya MurthyiD· 1 shared Ariane Nissenbaum· 1 shared Bob CheniD· 1 shared Brian L. YaspaniD· 1 shared Caden W. SweetiD· 1 shared Céline EidenschenkiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Mary E. KeirORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringNature CommunicationsPeer-reviewedJan 9, 2026

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

Meghan M. Capeling, Bob Chen, Kazeera Aliar…·Michelle B. Chen

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

5 citationstop 2%

humanscRNA-seq

𝕏 PostBluesky

ImmunologyNature GeneticsPeer-reviewedOct 23, 2024

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

Simone M. Haag, Shiqi Xie, Céline Eidenschenk…·Aditya Murthy

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

13 citations

mousehuman

𝕏 PostBluesky