Soluble guanylyl cyclase, the NO-receptor, regulates endothelium-dependent vascular relaxation via its transnitrosation activity.
Waqas Younis, Pía C. Burboa, Tanaz Sadeghian, Veronica Kuzdowicz, Chuanlong Cui, Ping Shu, Yong Qin, Lai‐Hua Xie, Mauricio A. Lillo, Annie V. Beuve
This study shows that the C610S mutation in GC1 disrupts endothelium-dependent vascular relaxation by impairing S-nitrosation, despite normal NO-cGMP signaling.
Proceedings of the National Academy of Sciences · Oct 2, 2025Peer-reviewedBiochemistry