Pía C. Burboa

Impaired S-nitrosylation of Cx43 prevents arrhythmogenicity and myocardial injury upon cardiac stress in Duchenne Muscular Dystrophy

This study shows that reducing S-nitrosylation of Cx43 in DMD mice prevents arrhythmias and myocardial injury under cardiac stress.

Soluble guanylyl cyclase, the NO-receptor, regulates endothelium-dependent vascular relaxation via its transnitrosation activity.

This study shows that the C610S mutation in GC1 disrupts endothelium-dependent vascular relaxation by impairing S-nitrosation, despite normal NO-cGMP signaling.

Endothelial TRPV4/Cx43 Signaling Complex Regulates Vasomotor Tone in Resistance Arteries

This study shows TRPV4 activation modulates endothelial Cx43 hemichannels via S-nitrosylation, influencing Ca2+ levels and vasomotor tone in resistance arteries.