The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1.
Veronica Nuccetelli, Makram Mghezzi-Habellah, Séverine Deymier, Armelle Roisin, Francine C. A. Gérard, Cecilia Rocchi, Pierre‐Damien Coureux, Patrice Gouet, Andrea Cimarelli, Vincent Mocquet, Francesca Fiorini
This study shows that SARS-CoV-2 Np inhibits NMD by blocking UPF1 activity and disrupting UPF1/UPF2 complex formation, revealing a novel mechanism of viral evasion.
Nucleic Acids Research · Jan 11, 2025Peer-reviewedBiochemistry