Author

Armelle Roisin

Lyon 1 Université

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Makram Mghezzi-Habellah· 2 shared Vincent MocquetiD· 2 shared Alexandra Desrames· 1 shared Andrea CimarelliiD· 1 shared Cecilia RocchiiD· 1 shared David CluetiD· 1 shared Didier DécimoiD· 1 shared Fabrice LejeuneiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Makram Mghezzi-Habellah

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2 papers

Recent·Most cited

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.

Léa Prochasson, Makram Mghezzi-Habellah, Armelle Roisin, Martine Palma, Jean-Philippe Robin, Stève de Bossoreille, David Cluet, Malèke Mouelhi, Didier Décimo, Alexandra Desrames, Thibault Chaze, Mariette Matondo, Hélène Dutartre, Maria‐Isabel Thoulouze, Fabrice Lejeune, , Vincent Mocquet

This paper shows that HTLV-1 Rex hijacks CRM1 to retain UPF1 in the nucleus, inhibiting NMD and enabling UPF1 to support viral replication.

Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology

The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1.

Veronica Nuccetelli, Makram Mghezzi-Habellah, Séverine Deymier, Armelle Roisin, Francine C. A. Gérard, Cecilia Rocchi, Pierre‐Damien Coureux, Patrice Gouet, Andrea Cimarelli, Vincent Mocquet, Francesca Fiorini

This study shows that SARS-CoV-2 Np inhibits NMD by blocking UPF1 activity and disrupting UPF1/UPF2 complex formation, revealing a novel mechanism of viral evasion.

Nucleic Acids Research · Jan 11, 2025Peer-reviewedBiochemistry