BiochemistryNucleic Acids ResearchPeer-reviewed
The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1.
Veronica Nuccetelli, Makram Mghezzi-Habellah, Séverine Deymier…·Francesca Fiorini
This study shows that SARS-CoV-2 Np inhibits NMD by blocking UPF1 activity and disrupting UPF1/UPF2 complex formation, revealing a novel mechanism of viral evasion.
10 citations