Author

Vincent Mocquet

Lyon 1 UniversitéORCID 0000-0003-4337-5278Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Armelle Roisin· 2 shared Makram Mghezzi-Habellah· 2 shared Alexandra Desrames· 1 shared Andrea CimarelliiD· 1 shared Cecilia RocchiiD· 1 shared David CluetiD· 1 shared Didier DécimoiD· 1 shared Fabrice LejeuneiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Armelle Roisin

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2 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedMay 10, 2025

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.

Léa Prochasson, Makram Mghezzi-Habellah, Armelle Roisin…·Vincent Mocquet

This paper shows that HTLV-1 Rex hijacks CRM1 to retain UPF1 in the nucleus, inhibiting NMD and enabling UPF1 to support viral replication.

1 citation

humanexperimental assay

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedJan 11, 2025

The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1.

Veronica Nuccetelli, Makram Mghezzi-Habellah, Séverine Deymier…·Francesca Fiorini

This study shows that SARS-CoV-2 Np inhibits NMD by blocking UPF1 activity and disrupting UPF1/UPF2 complex formation, revealing a novel mechanism of viral evasion.

10 citations

humanexperimental assay

𝕏 PostBluesky