Presynaptic precursor vesicles originate from the trans-Golgi network, promoted by the small GTPase RAB2
Torsten Götz, Dmytro Puchkov, Veronika Lysiuk, Janine Lützkendorf, Alexander G. Nikonenko, Christine Quentin, Martin Lehmann, Stephan J. Sigrist, Astrid G. Petzoldt
The paper identifies RAB2's role in presynaptic precursor vesicle biogenesis at the trans-Golgi network, showing its necessity for proper protein transport and neurotransmission.
The Journal of Cell Biology · Feb 27, 2021Peer-reviewedNeuroscience