Stephan J. Sigrist

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

This study shows that Bruchpilot remodeling couples synaptic structure to Kv1/Shaker channel control of excitability, restoring function in sleepless mutants.

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

This study shows that octopamine rapidly potentiates presynaptic neurotransmitter release in Drosophila by clustering Unc13 via diacylglycerol signaling, affecting synaptic function and behavior.

This study shows that autophagy in Drosophila mushroom bodies regulates synaptic architecture and sleep resilience by modulating presynaptic active zone proteins and triggering a systemic proteostatic stress response.

This study shows that a constitutively active form of Unc13A reduces sleep rebound after deprivation, suggesting a role for SNARE complex dynamics in sleep homeostasis.

This study modifies the TsodyksMarkram Model to incorporate Unc13 isoforms, showing how they regulate short-term synaptic plasticity in fruit flies.

The paper shows that insomniac Drosophila mutants exhibit enhanced memory and mushroom body overgrowth, which are modulated by PKA signaling, suggesting a link between cognitive hyperplasticity and sleep deficits.

This study identifies Blobby as a novel regulator of presynaptic active zone nanopatterning and shows its role in maintaining Ca2+ channel packing density and synaptic function.

This study identifies an antagonistic interaction between Spinophilin and Syd-1 that regulates presynaptic long-term plasticity and olfactory memory in Drosophila.

The paper shows that presynaptic active zone plasticity (PreScale) influences brain resilience to aging in Drosophila by linking sleep, memory, and longevity.

This study shows that homeostatic presynaptic plasticity in Drosophila mushroom body neurons is essential for memory consolidation.

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

This paper shows that depletion of Drosophila CNBP causes age-dependent locomotor defects linked to reduced polyamine metabolism and ODC levels, which can be rescued by polyamine supplementation or ODC overexpression.

The paper investigates presynaptic long-term potentiation in hippocampal mossy fibers, finding increased glutamate release surface area and structural remodeling without changes in calcium channel coupling.

The paper identifies RAB2's role in presynaptic precursor vesicle biogenesis at the trans-Golgi network, showing its necessity for proper protein transport and neurotransmission.

This study shows that Spermidine, an autophagy activator, reduces neuroinflammation and Aβ levels in AD-like mice by enhancing autophagy in microglia and astrocytes.

NOSA is an open-source software for analyzing voltage imaging data, offering tools to improve signal processing and identify temporal interactions in neural activity.

The paper identifies delta oscillations in Drosophila's R2 network that regulate sleep, showing synchronization depends on NMDARs and input pathways, and disrupting this mechanism abolishes oscillations and impairs sleep.

This study shows RIM-BP2 has different roles in neurotransmitter release at hippocampal mossy fiber and pyramidal CA3-CA1 synapses, with RIM-BP2 promoting vesicle docking/priming at mossy fibers by recruiting Munc13-1.

The paper shows that Tao kinase regulates synaptic growth and connectivity in Drosophila nociceptive circuits to maintain specificity and function during larval development.

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.

The paper identifies a lineage-related reciprocal inhibition circuit in Drosophila that mediates sensory-motor action selection through competitive inhibition.