Author

Astrid G. Petzoldt

Freie Universität BerlinORCID 0000-0002-4059-7142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Martin LehmanniD· 2 shared Stephan J. SigristiD· 2 shared Alexander G. NikonenkoiD· 1 shared Alexander M. WalteriD· 1 shared Ali Pejmun HaghighiiD· 1 shared Andranik IvanoviD· 1 shared Andreas Till GrasskampiD· 1 shared Anne AstiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Martin LehmannORCID

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3 papers

Recent·Most cited

Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked

Anne Ast, Leonard Roth, Lydia Brusendorf, Franziska Schindler, Orchid Ammar, Sofie Berberich, Juliane Edel, Megan Bonsor, Elisabeth Georgii, Christian Haenig, Claudia Langnick, Andranik Ivanov, Dieter Beule, Marie Piraud, Séverine Kunz, , Erich E. Wanker

This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.

bioRxiv · Feb 6, 2025 · PreprintMolecular Biology

Presynaptic precursor vesicles originate from the trans-Golgi network, promoted by the small GTPase RAB2

Torsten Götz, Dmytro Puchkov, Veronika Lysiuk, Janine Lützkendorf, Alexander G. Nikonenko, Christine Quentin, Martin Lehmann, Stephan J. Sigrist, Astrid G. Petzoldt

The paper identifies RAB2's role in presynaptic precursor vesicle biogenesis at the trans-Golgi network, showing its necessity for proper protein transport and neurotransmission.

The Journal of Cell Biology · Feb 27, 2021Peer-reviewedNeuroscience

Rapid active zone remodeling consolidates presynaptic potentiation

Mathias A. Böhme, Anthony W. McCarthy, Andreas Till Grasskamp, Christine Brigitte Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Ali Pejmun Haghighi, Stefan W. Hell, David Owald, , Alexander M. Walter

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.

Nature Communications · Mar 6, 2019Peer-reviewedNeuroscience