Dmytro Puchkov

Damage sensing recruitment of a lipid phosphatase couples lysosomal membrane repair to proteostatic adaptation

This study shows MTMR14 is recruited to damaged lysosomes to remodel lipids, reduce mTORC1 signaling, and support proteostasis during lysosomal injury.

Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth

This study shows that dietary lipids induce caveolae uptake, caveolin1 accumulation to lipid droplets, and caveolin1-dependent lipid droplet growth.

Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions

The paper uses integrative molecular dynamics simulations to analyze cross-linking mass spectrometry data and reveal mitochondrial protein distributions, including the localization of FAM162A and TMEM126A in cristae.

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

This study identifies mitochondrial adaptations in naked mole-rats that confer hypoxia resistance, linking social behavior to molecular evolution.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

Presynaptic precursor vesicles originate from the trans-Golgi network, promoted by the small GTPase RAB2

The paper identifies RAB2's role in presynaptic precursor vesicle biogenesis at the trans-Golgi network, showing its necessity for proper protein transport and neurotransmission.

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum

This study shows that neuronal autophagy regulates axonal ER calcium stores to control neurotransmission and postnatal viability in mice.