SPTF-3/SP1 orchestrates mitochondrial biogenesis upon ribosomal stress and acute starvation
Johannes CW Hemerling, Victor Pavlenko, Marija Herholz, Linda C. Baumann, Aleksandra Zečić, Alexandra Kukat, Milica Popović, Karolina Szczepanowska, Estela Cepeda Cores, David Vı́lchez, Leo Kurian, Aleksandra Trifunović
The paper identifies SPTF-3 as a stress-induced transcription factor regulating mitochondrial biogenesis and UPRmt in C. elegans, with its mammalian homolog SP1 showing conserved function in nutrient deprivation.
bioRxiv · Aug 18, 2023 · PreprintMolecular Biology