Topology control by a conserved cysteine pair in the OMM-protein CCDC127 enables MICOS interaction
Christine Zarges, Pauline Schepsky, Robin Alexander Rothemann, Tobias Bock-Bierbaum, Alexander von der Malsburg, Linda C. Baumann, Aleksandra Trifunović, Oliver Daumke, Martin van der Laan, Karina von der Malsburg, Jan Riemer
The paper identifies CCDC127 as a mitochondrial disulfide relay substrate that interacts with MICOS components, revealing its role in OMM topology and mitochondrial membrane organization.
bioRxiv · Dec 15, 2025 · PreprintBiochemistry