Leo Kurian

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

This study identifies QKI as a regulator of splicing fidelity during cardiogenesis by interacting with U6 snRNA to enhance splicing at weak 5' splice sites.

This study identifies long non-coding RNAs (lncRNAs) as guides for the SWI/SNF complex to cell-specific enhancers, revealing a mechanism for chromatin accessibility and gene expression control.

The paper identifies SPTF-3 as a stress-induced transcription factor regulating mitochondrial biogenesis and UPRmt in C. elegans, with its mammalian homolog SP1 showing conserved function in nutrient deprivation.

The paper identifies circRAB3IP as a circRNA that modulates cell proliferation by altering gene expression and mRNA processing through interactions with SF3B1 in a paracrine manner.

The paper shows that RBPMS controls mRNA translation in pluripotent hESCs to preset cardiac fate competence, which is critical for cardiogenesis.