Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
Federica Mosti, Jing Liu, Katie Lam, Noah R. Dillon, Samantha Skavicus, Victoria A. Kapps, Ketrin Gjoni, Chia-Fang Lee, Emily N. Glidewell, Nicholas S. Heaton, Katherine S. Pollard, Debra L. Silver
The paper shows human-specific enhancer HAR1984 promotes neurogenesis by altering chromatin interactions and gene regulation in cortical organoids and mice.
Cell stem cell · Mar 19, 2026Peer-reviewedDevelopmental Biology