Debra L. Silver

The paper identifies 1,596 Consensus HAQERs by aligning T2T assemblies, showing they are rapidly evolved regions with mutation signatures, regulatory functions, and disease associations.

This study identifies molecular layer heterotopias and age-dependent cortical expansion in Chd8 haploinsufficient mice, linking them to neuronal migration defects and autism-related brain overgrowth.

The paper shows human-specific enhancer HAR1984 promotes neurogenesis by altering chromatin interactions and gene regulation in cortical organoids and mice.

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

The paper identifies a subcellular transcriptome in radial glia, revealing localized gene regulation and its role in cortical development.

The paper shows human-specific variants in HARE5 enhance enhancer activity, promoting progenitor proliferation and contributing to human cortical expansion.

The paper shows that RNA stability controls neurogenesis in the developing cortex by regulating gene expression through the CCR4-NOT complex.

This study shows EIF4A3 controls axonal tract formation by directly regulating microtubule dynamics in neurons, independent of its RNA-binding function.

The paper identifies GC content in coding sequences as a key factor in mRNA stabilization following DDX3X depletion, supported by analysis of RNA-seq data and ENCODE datasets.

This study shows EIF4A3 controls mitosis duration and cell survival in mouse and human neural progenitors, linking it to neurodevelopmental disorders.

The paper uses in vivo proximity labeling to analyze the subcellular proteome of radial glial cells and identifies non-muscle myosins that regulate endfoot structure and interneuron organization.

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

The paper shows that Arhgap11a mRNA localization and local translation in radial glial cells control cortical development by regulating RGC morphology and neuron positioning.

This study identifies DDX3X mutations as causing neurodevelopmental disorders by disrupting RNA metabolism and neurogenesis during fetal cortical development.